A plot to kill Paul makes him decide to travel by land to Jerusalem with a large team. On the way he visits the churches he has established to encourage them and organise leadership. At Troas, he shared with the church at length; Eutychus fell out of a window and died but then was resurrected.

Paul went to Philippi. He met Lydia at the place of prayer. She responded to the Gospel message. A slave girl disrupted Paul's work until he cast out the evil spirit from her in the name of Jesus, causing her owners to lose income. They took Paul and Silas to the magistrates, who beat and imprisoned them. Overnight God set them free through an earthquake. The jailer was saved and the magistrates escorted Paul and Silas out of the city.

Following a disagreement between Paul and Barnabas, they separated and Paul took Silas on his journey. The Holy Spirit hinders his progress in Bithynia and Paul has a vision of a man from Macedonia calling him to go there - to Europe.